Had a problem where the network access from a site in Africa to an Australian (Azure) based web site was very slow.
Instead created IPSEC links to a virtual Fortigate appliance in azure which was in a “close” geographic site (France Central), then used Microsoft premium peering between that Azure virtual network and one in Australia. Created an IPSEC link between the two Azure nets which meant we could use the web access from the Australian one from the African end of the chain.
This saved around 100ms in latency (with some other tweaks of the on site firewalls) and seems to have helped the performance of the web application.